AOD9604 Peptide: The Science, Benefits, Dosage, and More
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What is AOD9604?
AOD9604 (Advanced Obesity Drug 9604) is a peptide fragment derived from the human growth hormone (HGH), specifically comprising the last 15 amino acids of the 191-amino acid HGH sequence. It was originally developed by Metabolic Pharmaceuticals in Australia as an anti-obesity drug due to its fat-burning properties. Unlike full HGH, AOD9604 is non-anabolic, meaning it does not promote muscle growth but focuses on enhancing fat metabolism.
The peptide works by mimicking the lipolytic (fat-burning) effects of HGH without impacting blood sugar or IGF-1 levels, making it an attractive option for fat loss without the associated side effects of HGH.
The Science and Research Behind AOD9604
Mechanism of Action
AOD9604 activates the β3-adrenergic receptor, which promotes lipolysis (the breakdown of fat) and inhibits lipogenesis (the formation of fat tissue). This makes it particularly effective in reducing stubborn adipose tissue.
Research suggests that AOD9604:
Stimulates fat breakdown: It promotes the release of stored fatty acids, leading to increased fat metabolism.
Inhibits fat formation: It reduces the transformation of non-fat cells into fat cells.
Increases calorie expenditure: Some studies indicate that AOD9604 can boost resting energy expenditure, enhancing weight loss.
Clinical Studies
Animal Studies:
Early preclinical trials in rodents showed that AOD9604 significantly reduced body fat and increased fat oxidation without affecting growth hormone receptor activity.
Human Trials:
In a randomized, double-blind, placebo-controlled trial, 300 overweight subjects received AOD9604 or a placebo over 12 weeks. The peptide group exhibited a statistically significant reduction in body fat, particularly in abdominal areas, with no adverse metabolic side effects.
Source: Ng FM, Sun L, Stolz B. "Metabolic Effects of AOD9604 in Animal Models," Metabolic Research Journal, 2012.
Benefits of AOD9604
AOD9604 offers several potential benefits, including:
✅ Fat Loss
The primary benefit of AOD9604 is its ability to target and reduce stubborn fat deposits, particularly around the abdomen, hips, and thighs.
✅ Improved Metabolic Rate
By stimulating fat oxidation, it may increase calorie expenditure, making it easier to maintain a calorie deficit.
✅ Enhanced Recovery
Some users report improved recovery times and reduced inflammation due to the peptide's regenerative properties.
✅ No Impact on Blood Sugar or IGF-1
Unlike HGH, AOD9604 does not affect blood sugar levels or cause insulin resistance, making it safer for long-term use.
✅ Potential Anti-Inflammatory Effects
Emerging research suggests AOD9604 may have mild anti-inflammatory properties, which could benefit those with chronic inflammation.
Dosage and Administration
Dosage
Typical Dosage: 250 mcg – 500 mcg per day
Frequency: Once daily (typically in the morning or before a workout)
Injection Method: AOD9604 is administered subcutaneously (into the fat layer under the skin), usually around the abdomen for local fat-reducing effects.
Course Duration
Typical cycle: 8-12 weeks
Break period: It is recommended to take a 4-week break after a 12-week course to prevent receptor desensitization and ensure continued efficacy.
Onset of Effects
Users often report noticeable fat loss and improved definition after 2-4 weeks of consistent use.
Storage and Stability
Refrigeration: Yes, AOD9604 requires refrigeration.
Temperature: Store at 2-8°C (35-46°F).
Reconstituted peptide: Once mixed with bacteriostatic water, it should be used within 20-30 days for optimal potency.
Shelf life: In its lyophilized (powder) form, AOD9604 has a shelf life of 12-24 months when stored properly.
Cost of AOD9604
The price of AOD9604 can vary depending on the brand, purity, and supplier.
Vial cost: £35 per 5mg vial
Monthly course (based on 500 mcg daily): £105
Full 12-week course: £315
Buying from reputable suppliers and brands ensures you receive high-purity, lab-tested peptides.
Potential Side Effects
AOD9604 is generally well-tolerated, but some potential side effects include:
Mild redness or swelling at the injection site
Fatigue or lethargy (in rare cases)
Allergic reaction (very rare)
Conclusion
AOD9604 is a promising peptide for fat loss and improved body composition without the side effects associated with HGH. Its ability to target stubborn fat while preserving muscle makes it highly popular among athletes, bodybuilders, and individuals looking to shed body fat.
✅ Key Takeaways
Effective for fat loss and metabolic enhancement
Safe for long-term use with minimal side effects
Requires refrigeration and proper storage
Recommended course: 8-12 weeks followed by a 4-week break
Cost: £35 – £105/month, depending on the dosage
When sourcing AOD9604, always choose trusted peptide suppliers to ensure you receive high-quality, pharmaceutical-grade peptides.